Custom Peptides
Cayman Chemical UDPNacetylDGlucosamIns 10mg
A nucleotide sugar that is used by glycosyltransferases to transfer N-acetylglucosamine residues to substrates
Cayman Chemical D-Mnose-6-PhosphatesodIum 10mg
A phosphorylated aldohexose that can be used to produce glucose, mannitol, or N-glycans; also a ligand for both cation-dependent and -independent receptors and binds, as part of an N-glycan, to MRH domains on other proteins
Cayman Chemical SW203668trIfluoROCTAte sa 10mg
An irreversible inhibitor of stearoyl-CoA desaturase (IC50 = 54 nM); selectively cytotoxic to cancer cell lines that express CYP4F11 over those that don't (IC50s = 22-116 and >10,000 nM, respectively); reduces tumor growth rate without reducing sebocyte production in the H2122 wild-type and NOD-SCID mouse xenograft models at 20 and 6 mg/kg, respectively
Cayman Chemical CARFILZOMIB 10MG
An irreversible inhibitor of the chymotrypsin-like β5 subunit of the constitutive 20S proteasome (IC50 = 5.2 nM) and the β5i subunit of the immunoproteasome 20Si (LMP7; IC50 = 14 nM) with minimal cross reactivity to other proteases; induces cell cycle arrest and apoptosis in human cancer cell lines including multiple myeloma, lymphoma, and various solid tumors (IC50s = 2.4-20 nM)
Cayman Chemical ParaxnthIn 10mg
An active metabolite of caffeine; an adenosine A1 and A2 receptor antagonist (Kis = 35 and 22 µM, respectively); increases striatal cGMP and extracellular striatal dopamine levels and locomotor activity, as well as inhibits motor depression induced by CPA or CGS 21680 in rats not habituated to caffeine at 30 mg/kg; promotes wakefulness and increases locomotor activity and core temperature in narcoleptic transgenic mice without increasing behavioral anxiety
Cayman Chemical TetrabenazIn 10mg
An inhibitor of VMAT2 that is selective over VMAT1 (Kis = 97 and >20,000 nM, respectively, in a serotonin uptake assay); dose-dependently reduces levels of the monoamines norepinephrine, dopamine, and 5-HT in rat brain; has been used to induce depressive-like behavior in animal models; improves performance in balance beam and rotarod tests and prevents decreases in the number of striatal MSNs in a YAC128 transgenic mouse model of Huntington’s disease at 5 mg/kg
Cayman Chemical 1PalmItoyl2Oleoylsnglyce 10mg
A phospholipid; a major component of E. coli bilayers; vesicles composed of 1,2,-POPE can be disrupted by polycationic antimicrobials; has been used in combination with other lipids in the formation of LNPs for spleen- and liver-specific targeting in mice
Cayman Chemical MesorIdazIn 10mg
An active metabolite of thioridazine; formed via sulfoxidation of thioridazine by CYP2D6 in human liver microsomes; binds to histamine H1, dopamine D2, muscarinic acetylcholine, and α1- and α2-adrenergic receptors (Kds = 1.8, 19, 69, 2, and 1,600 nM, respectively); prevents mescaline-induced hyperactivity in mice at 10, 30, and 45 mg/kg
Cayman Chemical Glycoursodeoxycholc ACDd4 10mg
An internal standard for the quantification of glycoursodeoxycholic acid by GC- or LC-MS
Cayman Chemical DehydrolIthocholIc AcId 10mg
A major metabolite of lithocholic acid; formed from LCA by CYP3A4; an agonist of TGR5 (EC50 = 0.27 μM), VDR (EC50 = 3 μM), and FXR in cell-based reporter assays; binds to human PXR (IC50 = 15 μM) and activates mouse and human PXRs in cell-based reporter assays at 100 μM; binds to RORγt (Kd = 1.13 μM for the recombinant human ligand-binding domain) and decreases its activity in a cell-based reporter assay at 10 μM; inhibits the differentiation of TH17 cells at 20 μM
Cayman Chemical AdenylosuccInIc AcId 10mg
A purine nucleotide and an intermediate in the purine nucleotide cycle; converted into AMP and fumarate by ADSL in the cytosol; inhibits calcium-induced activation of non-selective cation channels in isolated rat brown adipocytes in a patch-clamp assay at 10 µM; induces contractions in isolated guinea pig uterus strips at 100 µM; increases glucose-induced insulin exocytosis in INS-1 832/13 insulinoma cells at 10 µM; decreases muscle damage and pseudohypertrophy in a dystrophin-deficient mdx mouse model of DMD
Cayman Chemical Upadacitinib 10mg
A JAK1 inhibitor (IC50 = 47 nM); selective for JAK1 over JAK3 and Tyk2 (IC50s = 2,304 and 4,690 nM, respectively), as well as a panel of 83 additional kinases at 1 µM, but does inhibit JAK2, ROCK1, and ROCK2 (IC50s = 120, 920 and 430 nM, respectively); decreases cytokine-induced STAT phosphorylation in a variety of human cells (IC50s = 1.6-649 nM); reduces M. tuberculosis-induced paw swelling and bone erosion in a rat model of arthritis at 1, 3, and 10 mg/kg twice per day for 17 days
Cayman Chemical IsolIthocholIc AcId 10mg
A bile acid; formed via microbial metabolism of LCA; inhibits TCA-induced spore germination in the C. difficile strains CD196, M68, BI9, and 630 at 0.01%, as well as inhibits growth and decreases the cytotoxicity of C. difficile culture supernatants to Vero cells at 0.0003%; fecal levels are decreased in a rat model of high-fat diet-induced obesity compared with rats fed a normal diet
Cayman Chemical GlycohyocholIc AcId 10mg
A glycine-conjugated form of hyocholic acid; upregulated 6.6-fold in the serum of patients with cirrhosis induced by HCV compared to healthy controls; plasma levels increase in patients who are no longer diabetic following gastric bypass surgery
Cayman Chemical N6MethyladenosIn 5monpho 10mg
An activator of glycogen phosphorylase b (Ka = 22 µM); a non-competitive inhibitor of rat adenylate kinase II; has been used for immunoprecipitation of N6-methyladenosine